Potential impact of the new WHO guidelines on the power in the HPTN071- PopART trial - Mathematical modelling as submitted to the HPTN 071 (PopART) DSMB not peer-reviewed by PLOS Medicine Executive summary
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HPTN 071 (PopART): A Cluster-Randomized Trial of the Population Impact of an HIV Combination Prevention Intervention Including Universal Testing and Treatment: Mathematical Model
BACKGROUND The HPTN 052 trial confirmed that antiretroviral therapy (ART) can nearly eliminate HIV transmission from successfully treated HIV-infected individuals within couples. Here, we present the mathematical modeling used to inform the design and monitoring of a new trial aiming to test whether widespread provision of ART is feasible and can substantially reduce population-level HIV incide...
متن کاملHPTN 071 (PopART): Rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment – a study protocol for a cluster randomised trial
BACKGROUND Effective interventions to reduce HIV incidence in sub-Saharan Africa are urgently needed. Mathematical modelling and the HIV Prevention Trials Network (HPTN) 052 trial results suggest that universal HIV testing combined with immediate antiretroviral treatment (ART) should substantially reduce incidence and may eliminate HIV as a public health problem. We describe the rationale and d...
متن کاملHIV Treatment-As-Prevention Research: Authors’ Reply
Till Bärnighausen and colleagues respond to comments by the HPTN 071 (PopART) Study Team, noting the distinction between the different HIV prevention questions the trial will attempt to answer.
متن کاملWhat works – reaching universal HIV testing: lessons from HPTN 071 (PopART) trial in Zambia
OBJECTIVE To determine the uptake of home-based HIV counselling and testing (HCT) in four HPTN 071 (PopART) trial communities (implementing a 'full' combination HIV prevention package that includes universal HIV testing and treatment) in Zambia. We also explore factors associated with uptake of HCT in these communities. DESIGN HPTN 071 (PopART) is a three-arm community-randomized trial in 12 ...
متن کاملHIV Treatment-As-Prevention Research: Taking the Right Road at the Crossroads
Reflecting on a Policy Forum article by Till Bärnighausen and colleagues, the HPTN 071 (PopART) Study Team consider ethical and study power concerns and the importance of the trial's future findings.
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